Toxicol Sci. It is a colorless, practically odorless, poisonous, and hygroscopic liquid with a sweetish taste. Please enable it to take advantage of the complete set of features! A meta description is an HTML tag in the HTML code of your website, which allows you to customize a section of text that describes the page itself. McKenzie BA, Robles-Najar J, Duong E, Brisk P, Grover WH. Diethylene glycol (DEG) is a clear, colorless, practically odorless, viscous, hygroscopic liquid with a sweetish taste. Absorption Disposition Metabolism Elimination (Dosed-Water; Gavage; Intravenous) (S0219) Completed . 2019 Dec;15(4):649-652. doi: 10.1007/s12024-019-00123-4. | INTENSIVE | RAGE | Resuscitology | SMACC. Diethylene glycol - Identification, toxicity, use, water pollution potential, ecological toxicity and regulatory information Note : See Working with the Information on this Page section below for important notes about this data. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Diethylene Glycol-d8 | C4H10O3 | CID 71309368 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. Introduction: 2013 Dec;51(10):923-9. doi: 10.3109/15563650.2013.850504. Schier JG, Hunt DR, Perala A, McMartin KE, Bartels MJ, Lewis LS, McGeehin MA, Flanders WD. 13533-05-6. COVID-19 is an emerging, rapidly evolving situation. … 2,2'-Oxydiethanol; Special Studies. 2010 Sep;117(1):25-35. doi: 10.1093/toxsci/kfq167. Propylene glycol poisoning is marked initially by CNS depression and an elevated osmolal gap and, later, by an increased anion gap. He has completed fellowship training in both intensive care medicine and emergency medicine, as well as post-graduate training in biochemistry, clinical toxicology, clinical epidemiology, and health professional education. This site uses Akismet to reduce spam. After finishing his medical degree at the University of Auckland, he continued post-graduate training in New Zealand as well as Australia’s Northern Territory, Perth and Melbourne. Merry Funtabulously Frivolous Friday Five 330. These cookies will be stored in your browser only with your consent. 2019 Apr 24;5(4):589-598. doi: 10.1021/acscentsci.8b00860. Following ingestion, DEG is rapidly absorbed and distributed within the body, predominantly to regions that are well perfused. But opting out of some of these cookies may have an effect on your browsing experience. In addition to its use in a wide range of industrial products, it has also been involved in a number of prominent mass poisonings spanning back to 1937. Undefined cookies are those that are being analyzed and have not been classified into a category as yet. Diethylene glycol poisoning can also result in hepatic disease, pancreatitis, and neurologic abnormalities, which appear up to a few days after exposure [8,12]. Diethylene glycol was found to be of low toxicity (BG Chemie 1989b). Chronoprints: Identifying Samples by Visualizing How They Change over Space and Time. It is miscible in water, alcohol, ether, acetone, and ethylene glycol. Toxicol Sci. Clinical features: Initial treatment consists of appropriate airway management and attention to acid-base abnormalities. For guinea pigs the oral LD 50 was 7.76 ml/kg body weight (about 8700 mg/kg body weight) and for rabbits … 3.1O acute toxicity (oral) 4 Acute Tox. Diethylene glycol (DEG) is a clear, colorless, practically odorless, viscous, hygroscopic liquid with a sweetish taste. Diethylene glycol (DEG) is a clear, colorless, practically odorless, viscous, hygroscopic liquid with a sweetish taste. T… The clinical effects of DEG poisoning can be divided into three stages: The first phase consists of gastrointestinal symptoms with evidence of inebriation and developing metabolic acidosis. -> ethanol dose (IV): 10% solution in D5W as a 40% solution, loading dose 7.5mL/kg -> 1-2mL/kg/hr-> ethanol dose (PO): quarter the above dose-> dose in CRRT: double IV dose-> maintain ethanol level @ 25-40mmol/L. Conclusions: Role of tissue metabolite accumulation in the renal toxicity of diethylene glycol. Despite the discovery of DEG’s toxicity in 1937 and its involvement in mass poisonings around the world, the information available regarding human toxicity is limited. Some authors suggest the minimum toxic dose is estimated at 0.14 mg/kg of body weight and the lethal dose is between 1.0 and 1.63 g/kg of body weight, while some suggest the LD50 in adults is of ~1 mL/kg, and others suggest this is the LD30. >1 mL/kg or a mouthful in a child is potentially lethal ethylene glycol itself is relatively non-toxic -> metabolites extremely toxic (glycolate) rate limiting step = alcohol dehydrogenase activity accumulation of glycolate -> direct cellular toxicity Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Diethylene glycol, dibenzoate. Epidemiology: Epub 2019 Mar 20. These cookies help provide information on metrics the number of visitors, bounce rate, traffic source, etc. C 1 8 H 1 8 O 5. Diethylene glycol (DEG) is a clear, colorless, odorless liquid with a sweet taste, and is an excellent solvent for water-insoluble chemicals and drugs. Clin Toxicol (Phila). Diethylene glycol (DEG) Diethylene glycol What is it? CNS depression begins soon after exposure, lasting for up to 12 hours after ingestion.  |  You also have the option to opt-out of these cookies. Toxicity and death may occur after drinking even a small amount. 2-(2-Hydroxyethoxy)ethyl acrylate. Out of these cookies, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. 4 H302 3.9 specific target organ toxicity - repeated exposure 2 STOT RE 2 H373 The most important adverse physicochemical, human health and environmental effects Safety Data Sheet acc. Diethylene glycol is toxic to humans and animals, and death can occur by renal failure. Although the mechanism of toxicity is not clearly elucidated, research suggests that the DEG metabolite, HEAA, is the major contributor to renal and neurological toxicities. We use cookies on our website to give you the most relevant experience by remembering your preferences and repeat visits. But more than 100 people died after taking the drug, and investigators from the US Food and Drug Administration (FDA) identified the drug’s solvent, diethylene glycol, as the killer. Diethylene Glycol Safety Data Sheet according to Federal Register / Vol. Management: These cookies do not store any personal information. 314.36 Molecular Formula. 30 minutes -> 12 hours post ingestion:excitement, confusion, disorientation -> ataxia, lethargy, stupor, coma, nausea/vomiting, myoclonus, seizures, cranial nerve deficits: nystagmus, ophthalmoplegia, facial palsy, dysarthria, dysphagia, 12 – 24 hours: progressive cardiorespiratory failure, ethylene glycol level (rarely useful acutely due to delays in obtaining result), severe metabolic acidosis (high anion gap) from glycolic acid accumulation, very high lactate (artefactual as there is high cross reactivity between lactate and glycolate in laboratory analysis) -> high lactate with oxidase method, less high with lactate dehydrogenase method, calcium oxalate crystalluria (oxalate produced by ethylene glycol metabolism chelates Ca2+ -> formation of crystals) + hypocalcaemia, fluorescence of urine on exposure to UV light (automotive antifreeze solutions have this to identify cooling system leaks), goal = blockade of alcohol dehydrogenase -> so ethylene glycol isn’t converted to glycolate, decrease absorption: no techniques really effective, decrease production of toxic metabolites: ethanol or 4-methylpyrazole (not available in Australiasia), thiamine 100mg IV Q6 hrly – theoretical benefit to increase elimination, pyridoxine (vitamin B6) 50mg IV Q6hrly – theoretical benefit to increase elimination, don’t replace Ca2+ unless low enough to cause manifestations. Based on a work at https://litfl.com. 2014 Jun;52(5):470-8. doi: 10.3109/15563650.2014.914527. 2010 Jun;48(5):401-6. doi: 10.3109/15563650.2010.495347. U.S. Federal Regulations TSCA 12(b) Not applicable SARA 313 Not applicable SARA 311/312 Hazard CategoriesSee section 2 for more information CWA (Clean Water Act) Not applicable Clean Air Act Not applicable OSHA Occupational Safety and Health Administration This site needs JavaScript to work properly. drunk: automotive antifreeze, solvent, polish, paints, cosmetics, brake fluid, car wash fluid. If patients are stabilized, they may then enter the final phase with various delayed neuropathies and other neurological effects, sometimes fatal. FDA HISTORY OFFICE T he US Food and Drug Administration’s role in the … Despite DEG's toxicity and associated epidemics of fatal poisonings, a comprehensive review has not been published. They are based predominantly on reports following some epidemics of mass poisonings, which may underestimate toxicity. Toxicity. NIH Aim: Clin Toxicol (Phila). He is an internationally recognised Clinician Educator with a passion for helping clinicians learn and for improving the clinical performance of individuals and collectives. Epub 2019 Jul 1. Bhalerao A, Sivandzade F, Archie SR, Cucullo L. Curr Cardiol Rep. 2019 Aug 28;21(10):111. doi: 10.1007/s11886-019-1204-y. Approximately 50% of ingested EG is excreted unchanged by the kidneys; however, a series of oxidation reactions in the liver and kidneys metabolize the remaining EG. This website uses cookies to improve your experience while you navigate through the website. USA.gov. He is a co-founder of the Australia and New Zealand Clinician Educator Network (ANZCEN) and is the Lead for the ANZCEN Clinician Educator Incubator programme. Learn how your comment data is processed. Slaughter RJ, Mason RW, Beasley DM, Vale JA, Schep LJ. #FOAMed Medical Education Resources by LITFL is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. By clicking “Accept”, you consent to the use of ALL the cookies. EG is rapidly absorbed from the GI tract; in dogs, blood concentrations of EG peak within 3 hr of ingestion. Clinical Adjunct Associate Professor at Monash University, Australia and New Zealand Clinician Educator Network, Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License, >1 mL/kg or a mouthful in a child is potentially lethal, ethylene glycol itself is relatively non-toxic -> metabolites extremely toxic (glycolate), rate limiting step = alcohol dehydrogenase activity, accumulation of glycolate -> direct cellular toxicity. The aquatic toxicity data for the diethylene glycol ethers (DGEE, DGPE and DGHE) and diethylene glycol ether acetates (DGEEA and DGBEA) are considered separately because diethylene glycol ether acetates do not hydrolyze readily in water at environmental conditions. His one great achievement is being the father of two amazing children. In the liver, diethylene glycol is metabolized into 2-hydroxyethoxyacetic acid (aka HEAA) which is known to contribute to the renal and neurological damage that is characteristic of poisoning (Minns, 2012)(Schep et al., 2009)(Brent, 2001). Any cookies that may not be particularly necessary for the website to function and is used specifically to collect user personal data via analytics, ads, other embedded contents are termed as non-necessary cookies. Toxicokinetics: Necessary cookies are absolutely essential for the website to function properly.  |  Epub 2014 May 9. Wittschieber D, Heuberger K, Schulz R, Köhler H, Varchmin-Schultheiß K. Forensic Sci Med Pathol. Mechanisms of toxicity: Characterizing concentrations of diethylene glycol and suspected metabolites in human serum, urine, and cerebrospinal fluid samples from the Panama DEG mass poisoning. 2019 Jul 15;18(1):236. doi: 10.1186/s12936-019-2872-1. Long term outcomes may include kidney failure and brain damage. Opinion on diethylene glycol 5 1. Ethylene glycol poisoning is poisoning caused by drinking ethylene glycol. DEG has also been inappropriately substituted in pharmaceutical preparations for nontoxic constituents, resulting in more than a dozen epidemics of human poisoning, w… 77, No. Diethylene glycol is also illegally used as counterfeit glycerin in some nations and sold internationally as a component of cough syrup and toothpaste. Preference cookies are used to store user preferences to provide content that is customized and convenient for the users, like the language of the website or the location of the visitor. Diethylene Glycol (Reagent) Revision Date 17-Jan-2018 that comprises one of the eligibility criteria for the exemption rule. Controversies in the Management of Functional Constipation in Children. This depression appears similar to ethanol intoxication, but without the characteristic odor of alcohol. Testing Status of Diethylene glycol 10993-P . More often, these epidemics have occurred in developing and impoverished nations where there is limited access to intensive medical care and quality control procedures are substandard. Introduction: Diethylene glycol (DEG) is a clear, colorless, practically odorless, viscous, hygroscopic liquid with a sweetish taste. He is actively involved in in using translational simulation to improve patient care and the design of processes and systems at Alfred Health. Clin Toxicol (Phila). Diethylene glycol monoacrylate. Besenhofer LM, McLaren MC, Latimer B, Bartels M, Filary MJ, Perala AW, McMartin KE. Route/Organism Dose Effect We also use third-party cookies that help us analyze and understand how you use this website. Epub 2010 Jun 7. Epub 2013 Nov 25. In addition to its use in a wide range of industrial products, it has also been involved in a number of prominent mass poisonings spanning back to 1937. Quality of fixed dose artemether/lumefantrine products in Jimma Zone, Ethiopia. Laboratory findings in clinical assessment of diethylene glycol can include an elevated osmolar gap, elevated anion gap, elevated creatinine, and acidosis [8,11,12] .  |  DEG is used as a component of multiple different products including antifreeze preparations, cosmetics, lubricants, brake fluids, wallpaper strippers, heating/cooling fuel and as a plasticizer. Belew S, Suleman S, Mohammed T, Mekonnen Y, Duguma M, Teshome H, Bayisa B, Wynendaele E, D'Hondt M, Duchateau L, De Spiegeleer B. Malar J. UNII-V94WS8078J. A summary of the literature on DEG was compiled by systematically searching OVID MEDLINE and ISI Web of Science. He coordinates the Alfred ICU’s education and simulation programmes and runs the unit’s education website, INTENSIVE. Large doses and unusual circumstances are necessary for the development of propylene glycol toxicity. The EC/LC50 values for the diethylene glycol ethers in fish range January 2010 Molecular Weight. He is also the Innovation Lead for the Australian Centre for Health Innovation at Alfred Health and Clinical Adjunct Associate Professor at Monash University. Early symptoms include intoxication, vomiting and abdominal pain. Analytical cookies are used to understand how visitors interact with the website.